Oleander is a poisonous plant, containing the toxic steroidal aglycone cardenolide-type cardiac glycosides odorosiside, adigoside, and oleandrin, especially when consumed in large amounts. These compounds have a narrow therapeutic index and are toxic when ingested. Adverse effects after ingestion include weakness, diarrhoea, nausea, vomiting, headache, stomach pain, and death. Toxicity studies of animals concluded that birds and rodents were observed to be relatively insensitive to the administered oleander cardiac glycosides. Other mammals, however, such as dogs and humans, are relatively sensitive to the effects of cardiac glycosides and the clinical manifestations of "glycoside intoxication". It is also hazardous to animals such as sheep, horses, cattle, and other grazing animals, with as little as 100 g being enough to kill an adult horse. Plant clippings are especially dangerous to horses, as they are sweet. In July 2009, several horses were poisoned in this manner from the leaves of the plant. Symptoms of a poisoned horse include severe diarrhoea and abnormal heartbeat. This is aptly reflected in the plant's Sanskrit name aśvamāra (अश्वमार), a compound of aśva "horse" and māra "killing". In reviewing oleander toxicity cases seen in-hospital, Lanford and Boor concluded that, except for children who might be at greater risk, "the human mortality associated with oleander ingestion is generally very low, even in cases of moderate intentional consumption (suicide attempts)." In 2000, a rare instance of death from oleander poisoning occurred when two toddlers adopted from an orphanage ate the leaves from a neighbor's shrub in El Segundo, California.